Shopping Cart

Your shopping cart is currently empty

4,5-Dicaffeoylquinic acid

Name: 4,5-Dicaffeoylquinic acid
Brand: TargetMol
SKU: T2S1158
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T2S1158Cas No. 57378-72-0

Alias Isochlorogenic acid C, 3,4-Dicaffeoylquinic acid

1. 4,5-Dicaffeoylquinic acid (Isochlorogenic acid C) has antiviral activity, including anti-HIV-1 integrase activity. 2. 4,5-Dicaffeoylquinic acid (Isochlorogenic acid C) shows anti-hepatotoxic activity.

4,5-Dicaffeoylquinic acid

Copy Product Info

😃Good

Purity: 99.74%

Catalog No. T2S1158Alias Isochlorogenic acid C, 3,4-Dicaffeoylquinic acidCas No. 57378-72-0

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$38	In Stock	In Stock
5 mg	$81	In Stock	In Stock
10 mg	$117	In Stock	In Stock
25 mg	$192	In Stock	In Stock
50 mg	$278	In Stock	In Stock
100 mg	$363	In Stock	In Stock
200 mg	$579	-	In Stock
1 mL x 10 mM (in DMSO)	$109	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.74%

Color:White to Yellow

Resource Download

COA

Product Introduction

4,5-Dicaffeoylquinic acid AI Summary

4,5-Dicaffeoylquinic acid exhibits a broad spectrum of bioactivities. Primarily, it functions as an inhibitor of HIV integrase enzymes, particularly HIV-1 and HIV-2 integrases, showing potent IC50 values ranging from 250.0 nM to 790.0 nM in various assays, including the inhibition of 3'-processing and strand transfer processes. Apart from its antiviral properties, 4,5-Dicaffeoylquinic acid also demonstrates significant antioxidant activities, such as DPPH free radical scavenging, superoxide anion scavenging, and inhibition of lipid peroxidation. The compound additionally inhibits the formation of advanced glycation end-products and aldose reductase, with corresponding IC50 values of 6400.0 nM and 2300.0 nM. Furthermore, it shows inhibitory activity against amyloid beta (1 to 42)-mediated neurotoxicity, aggregation, and aggregates, indicating potential neuroprotective effects relevant to Alzheimer's disease. 4,5-Dicaffeoylquinic acid also inhibits cell proliferation in human U251 and rat C6 cells, exhibiting higher efficacy in the former. It suppresses 5HETE, LTB4, and 12-hydroxy-5,8,10-heptadecatrienoic acid formation in human polymorphonuclear leukocytes with high IC50 values in the nanomolar range. It also inhibits PTP1B with an IC50 value of 59400.0 nM and demonstrates activity against Leishmania major and human DHODH enzymes, as well as antitrypanosomal activity against Trypanosoma cruzi trypomastigotes..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	1. 4,5-Dicaffeoylquinic acid (Isochlorogenic acid C) has antiviral activity, including anti-HIV-1 integrase activity. 2. 4,5-Dicaffeoylquinic acid (Isochlorogenic acid C) shows anti-hepatotoxic activity.
Synonyms	Isochlorogenic acid C, 3,4-Dicaffeoylquinic acid

Chemical Properties

Molecular Weight	516.45
Formula	C₂₅H₂₄O₁₂
Cas No.	57378-72-0
Smiles	O[C@@H]1C[C@@](O)(C[C@@H](OC(=O)\C=C\c2ccc(O)c(O)c2)[C@H]1OC(=O)\C=C\c1ccc(O)c(O)c1)C(O)=O
Relative Density.	1.64 g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (484.07 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.87 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9363 mL	9.6815 mL	19.3630 mL	96.8148 mL
5 mM	0.3873 mL	1.9363 mL	3.8726 mL	19.3630 mL
10 mM	0.1936 mL	0.9681 mL	1.9363 mL	9.6815 mL
20 mM	0.0968 mL	0.4841 mL	0.9681 mL	4.8407 mL
50 mM	0.0387 mL	0.1936 mL	0.3873 mL	1.9363 mL
100 mM	0.0194 mL	0.0968 mL	0.1936 mL	0.9681 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc